anti-human/mouse PUMA Purified Polyclonal **

产品名称：anti-human/mouse PUMA Purified Polyclonal 100 ug
产品货号：eBioscience 14-6041-82
产品规格：100 ug
Anti-Human/Mouse PUMA Purified
Also known as: bbc3, p53 upregulated modulator of apoptosis
Clone: Polyclonal
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-6041
Cat. No. Size
14-6041-82  100 ug 
Description: The polyclonal antibody reacts with human and mouse PUMA. The antibody was raised against a synthetic peptide (plprghrapemepn) corresponding to amino acids 180 to 193 of human PUMA-α. This sequence is identical in α and β forms of the PUMA proteins. Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!