Anti-Human/Mouse Activation-Induced Cytidine Deaminase (MAID-2) Purified

产品名称：Anti-Human/Mouse Activation-Induced Cytidine Deaminase (MAID-2) Purified 100 ug
产品货号：eBioscience 14-5959-82
产品规格：100 ug
Anti-Human/Mouse Activation-Induced Cytidine Deaminase (AID) Purified
Also known as: AICID
Clone: mAID-2
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-5959
Cat. No. Size
14-5959-80  25 ug 
14-5959-82  100 ug 
Description: The monoclonal mAID-2 recognizes human and mouse AID (gene AICDA) also known as Activation-Induced Cytidine Deaminase. AID is a 24 kDa RNA-editing enzyme that converts cytosine into uracil. It plays a critical role during B cell development, specifically in somatic hypermutation (SHM) and immunoglobulin class switch recombination (CSR). Changes in levels of AID expression typically present with disease. For example, mutations in AID are found in Hyper-IgM Syndrome (type 2), a disease form without opportunistic infections, while overexpression correlates with poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma.AID is expressed mainly by activated mature B cells such as mature germinal centre (GC) B cells but also in intermediate GC cells (defined as IgD+CD38-CD23-CD71+). In addition to hematopoietic cells, AID is expressed in primary human hepatocellular carcinomas, helicobacter infected gastric epithelial cells, oocytes and embryonic stem cells although it role in these cells is not well understood. Because AID contains an NLS (nuclear localization signal), expression can be found both in the nucleus as well as in the cytoplasm.

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