Purified Human VEGFR1 (clone 7A6), **

产品名称：Purified Human VEGFR1 (clone 7A6), 100 ug
产品货号：eBioscience 14-5936-82
产品规格：100 ug
Anti-Human VEGF Receptor 1 (Flt1) Purified
Also known as: Vascular Endothelial Growth Factor Receptor 1, VEGF-R1, FLT-1, FMS-like tyrosine kinase 1, Tyrosine-protein kinase receptor FLT
Clone: 7A6
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-5936
Cat. No. Size
14-5936-80  25 ug 
14-5936-82  100 ug 
Description: This 7A6 monoclonal antibody recognizes human VEGFR1 (vascular endothelial growth factor receptor 1, fms-like tyrosine kinase 1, FLT1). It is directed against the extracellular domain and can recognize both membrane-bound and soluble forms of VEGFR1, with approximate molecular weights of 180 kDa and 90 kDa, respectively. Mice lacking expression of VEGFR1 have disorganized vasculature and die in utero, however angiogenesis does not require the tyrosine kinase activity of VEGFR1 as expression of a membrane-bound form lacking the tyrosine kinase domain allows normal development. Although fertile and viable, mice lacking the tyrosine kinase domain of VEGFR1 do have a defect in the migration of macrophages. The soluble form of VEGFR1 can be detected in the serum of normal patients, and elevated levels of soluble VEGFR1 in pregnant women is associated with preeclampsia. Several tumor cell lines have been reported to express membrane-bound VEGFR1, including malignancies of hematopoietic origin.

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