Purified anti-mouse ISG-15 **

产品名称：Purified anti-mouse ISG-15 (ISG15) 100 ug
产品货号：eBioscience 14-5857-82
产品规格：100 ug
Anti-Mouse ISG15 Purified
Also known as: ISG-15
Clone: 3C2
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-5857
Cat. No. Size
14-5857-80  25 ug 
14-5857-82  100 ug 
Description: This 3C2 monoclonal antibody reacts with mouse interferon stimulated gene-15 (ISG-15), a 15kDa ubiquitin-like protein (UBL) and cytokine. ISG-15 is translated as a precursor that is subsequently activated by an E1 enzyme, conjugated by an E2 enzyme via the C-terminal LRLRGG motif and ligated by an E3 ligase. The activity of ISG-15 is dependent on its modification of target proteins at specific lysine residues. Several viruses utilize ISG-15 and ubiquitin deconjugating proteases, while influenza B protein NS1 has been shown to specifically bind ISG-15 thereby blocking its conjugation.
In addition to its role as a protein modification, ISG-15 is secreted by monocytes and lymphocytes in response to IFNα, β, or γ, as well as influenza B virus. In this role as cytokine, it has been shown to induce secretion of IFNγ and support NK cell proliferation and cytolytic activity.

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