Anti-Mouse Ikaros (clone 2A9-mIkaros) Purified, **

产品名称：Anti-Mouse Ikaros (clone 2A9-mIkaros) Purified, 100 ug
产品货号：eBioscience 14-5780-82
产品规格：100 ug
Anti-Mouse Ikaros Purified
Also known as: IZKF1
Clone: 2A9-mIkaros
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-5780
Cat. No. Size
14-5780-80  25 ug 
14-5780-82  100 ug 
Description: This 2A9-mIkaros monoclonal antibody reacts with mouse Ikaros, the 70-kDa founding member of the Ikaros family of C2H2-type zinc finger transcription factors. Ikaros is expressed in hematopoietic progenitor cells, thymocytes, mature T and B cells, monocytes, macrophages, and natural killer cells. This protein has also been shown to be expressed in non-immune cells such as neurons. Studies indicate that Ikaros can interact with other family members, namely Aiolos and Eos. Ikaros is involved in thymocyte development, B cell differentiation, cell cycle control, chromatin remodeling, and tumor suppression. Moreover, Ikaros has been implicated in leukemia and lymphoma. Ikaros has been demonstrated to regulate expression of Tdt, CD8a, and Notch target genes.
At least eight Ikaros isoforms exist due to alternative splicing. The 2A9-mIkaros antibody has been reported to recognize Ikaros isoform VI (Ik-6), which is the longest and most predominant.

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