Purified Anti-Myogenin (clone F5D), **

产品名称：Purified Anti-Myogenin (clone F5D), 100 ug
产品货号：eBioscience 14-5643-82
产品规格：100 ug
Anti-Myogenin Purified
Also known as: MYOG
Clone: F5D
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-5643
Cat. No. Size
14-5643-80  25 ug 
14-5643-82  100 ug 
Description: This F5D monoclonal antibody reacts with human, mouse, dog, and rat myogenin, a 34-kDa transcription factor. Expressed in skeletal and heart muscle, myogenin is a member of the MyoD family of basic-helix-loop-helix proteins, which also includes MyoD, Myf5, and MRF4. This transcription factor interacts with other helix-loop-helix proteins, which may or may not be muscle-specific. Myogenin plays a significant role in myogenic differentiation, even directing nonmuscle cells to the myogenic lineage. Transforming growth factor-beta (TGFb) and bone morphogenetic protein-2 (BMP2) inhibit myogenin transcriptional activity. Predominantly residing within the nucleus, the subcellular localization of myogenin has been shown to be dependent on differentiation status and cell density. For instance, trafficking of myogenin between the nucleus and cytoplasm has been reported during skeletal muscle differentiation to mediate transcription control.

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