Anti-Human/Mouse CD325 (N-Cadherin) Purified (8C11)

产品名称：Anti-Human/Mouse CD325 (N-Cadherin) Purified (8C11) 100 ug
产品货号：eBioscience 14-3259-82
产品规格：100 ug
Anti-Human CD325 (N-Cadherin) Purified
Also known as: neural cadherin
Clone: 8C11
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-3259
Cat. No. Size
14-3259-80  25 ug 
14-3259-82  100 ug 
Description: The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 130 kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells.

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