anti-human CD182 (CXCR2, IL-8RB) Purified eBio5E8-C7-F10 (5E8-C7-F10)

产品名称：anti-human CD182 (CXCR2, IL-8RB) Purified eBio5E8-C7-F10 (5E8-C7-F10) 500 ug
产品货号：eBioscience 14-1829-82
产品规格：500 ug
Anti-Human CD182 (CXCR2) Purified
Also known as: Interleukin-8 Receptor B, IL8RB, IL98Rb, C-X-C chemokine receptor type 2, GRO/MGSA receptor
Clone: eBio5E8-C7-F10 (5E8-C7-F10)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-1829
Cat. No. Size
14-1829-82  100 ug 
14-1829-80  25 ug 
14-1829-85  500 ug 
Description: The eBio5E8-C7-F10 monoclonal antibody reacts with human CD182 (CXCR2, IL-8Rβ). CD182 is a 67-70 kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8Rα) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-α, -β and -γ, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.

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