eBioscience 14-0791-82 Purified mouse CD79a (clone 24C2.5), 100 ug

产品名称：Purified mouse CD79a (clone 24C2.5), 100 ug
产品货号：eBioscience 14-0791-82
产品规格：100 ug
Anti-Mouse CD79a Purified
Also known as: Ig-alpha, mb-1, Ly-54
Clone: 24C2.5
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-0791
Cat. No. Size
14-0791-80  25 ug 
14-0791-82  100 ug 
Description: This 24C2.5 monoclonal antibody reacts with the intracellular tail of mouse CD79a (also known as Ig alpha or mb-1), a signaling component of the B cell receptor (BCR). CD79a heterodimerizes with CD79b (Ig beta, B29), and together with surface Ig, make up the BCR. Both CD79 subunits consist of a single extracellular Ig domain, a transmembrane domain, and an intracellular signaling domain. CD79a is expressed almost exclusively on B cells, as well as in most B lineage acute lymphoblastic leukemias. The cytoplasmic domain of CD79a contains immunoreceptor tyrosine-based activation motifs (ITAMs), which constitute the signal transducing portions of the BCR. Tyrosine phosphorylation of these ITAMs by Syk and Lyn initiates numerous signaling cascades, resulting in B cell activation, proliferation, and differentiation.
 

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