eBioscience 14-0747-82 Anti-Human CD74 Purified (VIC-Y1) 100 ug

产品名称：Anti-Human CD74 Purified (VIC-Y1) 100 ug
产品货号：eBioscience 14-0747-82
产品规格：100 ug
Anti-Human CD74 Purified
Also known as: Invariant chain, Ia-gamma, Ii
Clone: VIC-Y1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-0747
Cat. No. Size
14-0747-80  25 ug 
14-0747-82  100 ug 
Description: This VIC-Y1 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43 kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFkB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.
The VIC-Y1 monoclonal antibody binds to a cytoplasmic region of human CD74 and thus cannot be used to detect cell surface expression of this molecule.
 

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