eBioscience 14-0333-82 anti-mouse siglec H - marker for IPC/pDC plasmacytoid DC

产品名称：anti-mouse siglec H - marker for IPC/pDC plasmacytoid DC Purified eBio440c 100 ug
产品货号：eBioscience 14-0333-82
产品规格：100 ug
Anti-Mouse Siglec H Purified
Also known as: Sialic Acid-Binding Immunoglobulin-Like Lectin H
Clone: eBio440c
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-0333
Cat. No. Size
14-0333-81  50 ug 
14-0333-82  100 ug 
Description: The monoclonal antibody eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction.
The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG).
It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.
 

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