eBioscience 13-5782-82 anti-mouse Ly49D Biotin (Clone: eBio4E5) 100 ug

产品名称：anti-mouse Ly49D Biotin (Clone: eBio4E5) 100 ug
产品货号：eBioscience 13-5782-82
产品规格：100 ug
Anti-Mouse Ly-49D Biotin
Also known as: Ly49D, Ly49
Clone: eBio4E5 (4E5)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 13-5782
Cat. No. Size
13-5782-80  25 ug 
13-5782-82  100 ug 
Description: The monoclonal antibody eBio4E5 (4E5) reacts with Ly-49D, an activating member of the Ly-49 family of NK cell receptors. This family of receptors form homodimers that recognize MHC Class I molecules. The activating Ly-49 receptors (Ly-49D and Ly-49H) do not contain immune receptor tyrosine-based inhibitory motifs (ITIM) in their cytoplasmic domains, distinguishing them from the inhibitory Ly-49 family members. Instead, activating Ly-49 molecules have been shown to associate with DAP12 which contains an immunoreceptor tyrosine-based activation motif (ITAM) that is required for positive signaling. Expression of different Ly-49 family members is not linked, therefore, several Ly-49 proteins can be expressed on the same cells. Expression of Ly-49D on subsets of NK cells is strain-dependent and is found in C57BL/6, CB6F1 and SJL mice, while BALB/c, DBA/2, AKR and CBA/J mice are negative for Ly-49D. In 129/J mice, eBio4E5 also recognizes Ly-49O, Ly-49V and Ly-49R. eBio4E5 is reported to have functional (activating) activity.
 

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