eBioscience 13-3392-82 Mouse Jagged-2 (clone HMJ2-1), 100 ug

产品名称：Mouse Jagged-2 (clone HMJ2-1), 100 ug
产品货号：eBioscience 13-3392-82
产品规格：100 ug
Anti-Mouse Jagged 2 Biotin
Also known as: JAG2
Clone: HMJ2-1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 13-3392
Cat. No. Size
13-3392-80  25 ug 
13-3392-82  100 ug 
Description: This HMJ2-1 monoclonal antibody reacts with mouse Jagged-2, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Jagged-2 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-2 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen.
Note: Staining of endogenous splenic dendritic (CD8+CD11c+) cells could only be consistently confirmed in cells isolated from C57BL/6, but not Balb/c, mice. Other strains have not been tested. The antiobdy has been reported to crossreact to rat and have blocking function.
 

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