eBioscience 13-1304-80 Biotin Human CNTFR alpha (clone AN-D3), 25 tests

产品名称：Biotin Human CNTFR alpha (clone AN-D3), 25 tests
产品货号：eBioscience 13-1304-80
产品规格：25 tests
Anti-Human Ciliary Neurotrophic Factor Receptor alpha Biotin
Also known as: CNTFRa, CNTF Receptor alpha, CNTF Ra
Clone: AN-D3
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 13-1304
Cat. No. Size
13-1304-80  25 ug 
13-1304-82  100 ug 
Description: This AN-D3 monoclonal antibody reacts with human ciliary neurotrophic factor receptor alpha (CNTFR alpha). CNTFR alpha expression is primarily localized to the nervous system and skeletal muscle. Together with gp130 and LIFR beta, this molecule forms the tripartite CNTF receptor complex. These receptor components remain unassociated until CNTF binds CNTFR alpha, which leads to their recruitment. Subsequent activation of the JAK-STAT pathway leads to changes in gene expression that affect cell survival and differentiation. More recently, another cytokine, neuropoietin, has been shown to bind the CNTFR receptor complex to promote nervous system development.
The AN-D3 antibody recognizes CNTFR alpha when it is dissociated from the tripartite complex.
 

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