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eBioscience 12-9999-41 Anti-Human CD184 (CXCR4) PE (12G5) 25 tests

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产品名称: eBioscience 12-9999-41 Anti-Human CD184 (CXCR4) PE (12G5) 25 tests
产品型号: 12-9999-41
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eBioscience 12-9999-41 Anti-Human CD184 (CXCR4) PE (12G5) 25 tests


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eBioscience 12-9999-41 Anti-Human CD184 (CXCR4) PE (12G5) 25 tests

产品名称:Anti-Human CD184 (CXCR4) PE (12G5) 25 tests
产品货号:eBioscience 12-9999-41
产品规格:25 tests
Anti-Human CD184 (CXCR4) PE
Also known as: Fusin
Clone: 12G5
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-9999
Cat. No. Size
12-9999-41  25 tests 
12-9999-42  100 tests 
Description: The 12G5 monoclonal antibody reacts with human CXCR4 (CD184), also termed Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD+ cells. CXCR4 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. 12G5 shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CXCR4), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.
 

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