eBioscience 12-9967-42 anti-human LAT (Linker for activation of T-cells) PE LAT

产品名称：anti-human LAT (Linker for activation of T-cells) PE LAT.10-17 (10-17) 100 tests
产品货号：eBioscience 12-9967-42
产品规格：100 tests
Anti-Human LAT PE
Also known as: Linker for activation of T-cells, pp36, 36 kDa phospho-tyrosine adapter protein
Clone: LAT.10-17 (10-17)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-9967
Cat. No. Size
12-9967-41  25 tests 
12-9967-42  100 tests 
Description: This LAT.10-17 (10-17) monoclonal antibody reacts with human Linker for Activation of T cells (LAT), which is essential for T cell receptor (TCR)-mediated signal transduction. Characterized as an integral transmembrane protein, this ~37-kDa molecule does not possess a true extracellular domain. Upon TCR/CD3 engagement, LAT localizes to lipid rafts and is tyrosine phosphorylated by ZAP-70, leading to the recruitment and activation of other downstream signaling molecules such as Grb-2, PLCγ, and PI3K. This adapter molecule has been shown to be required for T cell activation, as well as thymocyte and T regulatory cell development. In humans, LAT is expressed on peripheral blood lymphocytes, lymph nodes, and tonsil. Studies in mice have shown that LAT is expressed in thymocytes, T cells, mast cells, natural killer cells, megakaryocytes, platelets, and early B cells. This antibody does not crossreact with the mouse antigen.
 

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