eBioscience 12-9913-81 anti-mouse TWEAK PE MTW-1 50 ug

产品名称：anti-mouse TWEAK PE MTW-1 50 ug
产品货号：eBioscience 12-9913-81
产品规格：50 ug
Anti-Mouse CD255 (TWEAK) PE
Also known as: TNF-related weak inducer of apoptosis, APO3L
Clone: MTW-1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-9913
Cat. No. Size
12-9913-81  50 ug 
12-9913-82  100 ug 
12-9913-83  200 ug 
Description: The MTW-1 monoclonal antibody reacts with mouse TWEAK, a type II transmembrane TNF superfamily member with high identity to TNF in its extracellular portion. TWEAK transcript is expressed broadly in many ***** and fetal tissues. TWEAK is expressed as membrane bound and secreted forms. Interaction of TWEAK with its counter-receptor (Fn14, TWEAK-R) promotes secretion of IL-8, activation of NF-κB, proliferation of endothelial cells, and apoptosis in a number of human cell lines. Initially, DR3 was thought to be a receptor for TWEAK, but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. While TWEAK exhibits overlapping signaling functions to TNF, it is generally less effective in inducing apoptosis, giving rise to its name, TNF-like weak inducer of apoptosis.
 

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