eBioscience 12-6502-82 Anti-Human/Mouse TOX PE (TXRX10) 100 ug

产品名称：Anti-Human/Mouse TOX PE (TXRX10) 100 ug
产品货号：eBioscience 12-6502-82
产品规格：100 ug
Anti-Human/Mouse TOX PE
Also known as: Thymocyte selection-associated HMG box protein
Clone: TXRX10
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-6502
Cat. No. Size
12-6502-80  25 ug 
12-6502-82  100 ug 
Description: This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during beta-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4+ T cell development as a regulator of the CD4loCD8lo to CD4+CD8lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.
 

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