eBioscience 12-5887-81 anti-mouse LPAM-1 (Integrin a4b7) PE DATK32 (DATK-32) 50

产品名称：anti-mouse LPAM-1 (Integrin a4b7) PE DATK32 (DATK-32) 50 ug
产品货号：eBioscience 12-5887-81
产品规格：50 ug
Anti-Mouse Integrin alpha 4 beta 7 (LPAM-1) PE
Also known as: LPAM1, Integrin alpha4 beta7, Integrin alpha4beta7
Clone: DATK32 (DATK-32)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5887
Cat. No. Size
12-5887-81  50 ug 
12-5887-82  100 ug 
12-5887-83  200 ug 
Description: The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (α4β7), which is a heterodimer of the the 154 kDa α4 subunit and the 130 kDa β7 subunit. In mouse, the β7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.
 

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