eBioscience 12-5867-42 Anti-Mouse/Human Integrin beta7 PE (FIB504) 100 tests

产品名称：Anti-Mouse/Human Integrin beta7 PE (FIB504) 100 tests
产品货号：eBioscience 12-5867-42
产品规格：100 tests
Anti-Human/Mouse Integrin beta 7 PE
Also known as: Integrin b7 ITGB7
Clone: FIB504
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5867
Cat. No. Size
12-5867-42  100 tests 
Description: The FIB504 monoclonal antibody reacts with human and mouse integrin beta 7. Integrin beta 7 is a 130 kD glycoprotein which associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha 4 beta 7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alpha E beta 7 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.
 

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