eBioscience 12-5841-82 anti-mouse/human OCT3/4, Pou5f1, transcription factor 1

产品名称：anti-mouse/human OCT3/4, Pou5f1, transcription factor 1 PE EM92 100 ug
产品货号：eBioscience 12-5841-82
产品规格：100 ug
Anti-Human/Mouse OCT3/4 PE
Also known as: OCT4, Oct-4, Oct-3, OCT3, octamer-binding transcription factor, POU5F1, POU domain, class 5, transcription factor 1
Clone: EM92
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5841
Cat. No. Size
12-5841-80  25 ug 
12-5841-82  100 ug 
Description: The EM92 monoclonal antibody reacts with mouse and human Oct-3/4, encoded by the Pou5F1 gene. Oct-3/4 is a POU domain-containing transcription factor that is critical for maintaining embryonic stem (ES) cells in a pluripotent state, and is expressed by ES, embryonic germ cells and embryonic carcinoma cell lines. In cells of the inner cell mass (ICM), reduction of Oct-3/4 expression causes dedifferentiation to trophoectoderm, whereas increased expression results in differentiation to mesoderm and primitive endoderm. Oct-3/4 regulates the expression of several genes, including FGF-4, UTF1, Sox2, Fbx15, Rex1 and osteopontin through distinct mechanisms. Furthermore, Oct-3/4 frequently acts synergistically with Sox2 to regulate target gene expression, as is the case with FGF-4. It has been demonstrated that Oct-3/4 expression in ES cells can be negatively regulated by either treatment with retinoic acid, or by removal of leukemia-inhibitory factor (LIF).
 

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