eBioscience 12-5786-82 Anti-Human/Mouse Notch2 PE (16F11) 100 ug

产品名称：Anti-Human/Mouse Notch2 PE (16F11) 100 ug
产品货号：eBioscience 12-5786-82
产品规格：100 ug
Anti-Human/Mouse Notch2 PE
Also known as: NOTCH-2, Neurogenic locus notch homolog protein 2
Clone: 16F11
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5786
Cat. No. Size
12-5786-80  25 ug 
12-5786-82  100 ug 
Description: This 16F11 monoclonal antibody reacts with the extracellular domain of human and mouse Notch2, one of four members of the Notch family of receptors. Notch receptors are 300-kDa single-pass transmembrane proteins. While the extracellular domain contains numerous epidermal growth factor-like repeats for ligand binding, the intracellular domain is involved in cell signaling. Upon binding its membrane-bound ligand (either Delta or Jagged), the Notch receptor undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by γ-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription.
Notch2 is expressed on thymocytes (i.e., DN1 and DN2 subsets), activated peripheral T cells, and bone marrow. Moreover, expression of Notch2 has been reported to be altered in various cancers and lymphomas. In addition to its role in stem cell hematopoiesis, Notch2 plays a pivotal role in marginal zone B cell development. Notch2 also interacts with phosphorylated CREB1 to induce granzyme B transcription in cytotoxic T cells.
 

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