eBioscience 12-5765-80 Anti-Mouse Notch1 PE (22E5) 25 ug

产品名称：Anti-Mouse Notch1 PE (22E5) 25 ug
产品货号：eBioscience 12-5765-80
产品规格：25 ug
Anti-Mouse Notch1 PE
Also known as: Notch 1, TAN1, Neurogenic locus notch homolog protein 1
Clone: 22E5
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5765
Cat. No. Size
12-5765-80  25 ug 
12-5765-82  100 ug 
Description: This 22E5 monoclonal antibody reacts with the extracellular domain of mouse Notch1, one of four members of the Notch family of receptors. Notch receptors are 300-kDa single-pass transmembrane proteins. While the extracellular domain contains numerous epidermal growth factor-like repeats for ligand binding, the intracellular domain is involved in cell signaling. Upon binding its membrane-bound ligand (either Delta or Jagged), the Notch receptor undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription.
Notch 1 is expressed on thymocytes, bone marrow hematopoietic stem cells, T and NK cells. Lower Notch1 expression levels can be found on B cells and monocytes. Studies show that some subsets of T-cell acute lymphoblastic leukemia (T-ALL) arise due to Notch1 chromosomal translocation with TCRbeta, which results in the expression of constitutively active Notch1. This cell surface receptor is involved in T cell lineage commitment, thymocyte development, and Th2 differentiation.
 

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