eBioscience 12-5760-80 Anti-Mouse Bcl-6 PE (mGI191E) 25 ug

产品名称：Anti-Mouse Bcl-6 PE (mGI191E) 25 ug
产品货号：eBioscience 12-5760-80
产品规格：25 ug
Anti-Mouse Bcl-6 PE
Also known as: B cell lymphoma 6
Clone: mGI191E
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5760
Cat. No. Size
12-5760-80  25 ug 
12-5760-82  100 ug 
Description: This mGI191E monoclonal antibody reacts with mouse Bcl-6, which is also known as B-cell lymphoma 6. A member of the POZ family of transcriptional repressors, Bcl-6 is expressed most abundantly in germinal center B cells, as well as in differentiating and activated B cells. This 79-kDa protein is essential for germinal center B cell proliferation and survival. Moreover, during B cell development, Bcl-6 plays an important role in promoting pre-B cell survival to enable the generation of a diverse B cell repertoire. Moreover, Bcl-6 is expressed constitutively in diffuse large B cell lymphomas (DLBCLs), Burkitt’s lymphoma, and non-Hodgkin’s lymphoma. Reports also suggest expression of Bcl-6 in CD4+ T follicular helper cells and memory T cells. Bcl-6 has been reported to be antagonized by Blimp-1.

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