eBioscience 12-5499-42 Anti-Human TSLP Receptor PE (1A6) 100 tests

产品名称：Anti-Human TSLP Receptor PE (1A6) 100 tests
产品货号：eBioscience 12-5499-42
产品规格：100 tests
Anti-Human TSLP Receptor PE
Also known as: thymic stromal derived lymphopoietin receptor, CRLF-2
Clone: eBio1A6 (1A6)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5499
Cat. No. Size
12-5499-41  25 tests 
12-5499-42  100 tests 
Description: The eBio1A6 monoclonal antibody reacts with human thymic stromal-derived lymphopoietin receptor (TSLPR). TSLPR is an approximately 50 kDa protein with significant similarity to the common gamma-chain. TSLPR complexes with IL-7R alpha (CD127) to form the high affinity receptor that binds thymic stromal-derived lymphopoietin (TSLP). Human TSLPR is expressed by monocytes and CD11c+ dendritic cells, and TSLP binding induces the expression of the Th2 cell-attracting chemokines CCL17 and CCL22. Furthermore, the TSLPR-induced activation of dendritic cells indirectly results in the increased secretion of Th cytokines IL-4, -5 and -13, which may be necessary for the regulation of CD4+ T cell homeostasis. In mice, deficiency of TSLPR has no effect on lymphocyte numbers, whereas double deficiency of TSLPR and common gamma-chain results in fewer lymphocytes than seen in mice deficient in the common gamma-chain alone. The eBio1A6 monoclonal antibody is able to cross-block binding of another anti-human TSLPR monoclonal antibody, 1D8.
 

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!