eBioscience 12-5201-82 Phycoerythrin (PE) anti-mouse CD200R 100 ug

产品名称：Phycoerythrin (PE) anti-mouse CD200R 100 ug
产品货号：eBioscience 12-5201-82
产品规格：100 ug
Anti-Mouse CD200 Receptor PE
Also known as: CD200R, OX2R
Clone: OX110
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5201
Cat. No. Size
12-5201-80  25 ug 
12-5201-82  100 ug 
Description: The monoclonal antibody OX110 recognizes mouse CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNF alpha secretion.
Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells.
 

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