eBioscience 12-5179-42 Anti-Human CD85g (ILT7) PE eBio17G10.2 (17G10.2) 100 tes

产品名称：Anti-Human CD85g (ILT7) PE eBio17G10.2 (17G10.2) 100 tests
产品货号：eBioscience 12-5179-42
产品规格：100 tests
Anti-Human CD85g (ILT7) PE
Also known as: ILT-7, LILRA4
Clone: eBio17G10.2 (17G10.2)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5179
Cat. No. Size
12-5179-41  25 tests 
12-5179-42  100 tests 
Description: The eBio17G10.2 monoclonal antibody reacts with human immunoglobulin-like transcript 7 (ILT7), also known as CD85g. ILT7 is part of the leukocyte immunoglobulin-like receptor (LIR) gene family and associates with Fc epsilon R1 gamma to form a functional complex which transduces ITAM-mediated signals that negatively modulates TLR-induced type I IFN production by human plasmacytoid dendritic cells. ILT7 is expressed exclusively on plasmacytoid dendritic cells and is absent in monocyte derived DCs. Treatment with IL-3 or CpG causes a decrease in expression.
Double staining of human PBMCs with eBio17G10.2 and anti-pDC marker BDCA2 yields virtually complete co-staining. Cross linking of ILT7 with eBio17G10.2 antibody causes reduced transcription of IFN alpha1, IFN alpha2, IFN alpha4 and IFN beta.
 

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