eBioscience 12-5149-42 Anti-Human CD85d (ILT4) PE (42D1) 100 tests

产品名称：Anti-Human CD85d (ILT4) PE (42D1) 100 tests
产品货号：eBioscience 12-5149-42
产品规格：100 tests
Anti-Human CD85d (ILT4) PE
Also known as: LIR2, LILRB2, MIR10
Clone: 42D1
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5149
Cat. No. Size
12-5149-71  25 tests 
12-5149-41  25 tests 
12-5149-42  100 tests 
Description: The monoclonal antibody 42D1 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leukocyte Ig-like receptor), MIR (monocytes Ig-like receptor) family. CD85d is a 110 kDa single transmembrane receptor with 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally, it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection.
Crosslinking of the receptor with the monoclonal antibody 42D1 inhibits calcium flux as well as enhancing HLA-G tetramer staining and restoring the stimulating activity of tolerogenic DC.
 

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