eBioscience 12-5119-42 Anti-Human ILT1 (CD85h, LIR7, LILRA2) PE (135.4) 100 tes

产品名称：Anti-Human ILT1 (CD85h, LIR7, LILRA2) PE (135.4) 100 tests
产品货号：eBioscience 12-5119-42
产品规格：100 tests
Anti-Human CD85h (ILT1) PE
Also known as: ILT-1, LIR7, LILRA2
Clone: 135.4
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-5119
Cat. No. Size
12-5119-41  25 tests 
12-5119-42  100 tests 
Description: The monoclonal antibody 135.4 recognizes ILT1, also known as CD85h, LIR7 and LILRA2. ILT1 is a member of the large family of ILT molecules (Immunologulin-like Transcripts) also known as Leukocyte Ig-like Receptors (LIRs) and Monocyte/Macrophage Ig-like Receptors (MIRs). ILT1 contains a short cytoplasmic domain. Through the cytoplasmic domain ILT1 associates with the Fc receptor γ chain but not DAP12 resulting in a stimulatory signal. ILT1 may act as a receptor for MHC Class I antigens. Expression of ILT1 is mainly found on monocytes, macrophages, DC and weakly on granulocytes. ILT1 is thought to play a role in the TH1/Th2 balance as well as TLR signaling. The monoclonal antibody 135.4 has been reported to have activating properties upon crosslinking which result in calcium influx.
 

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