eBioscience 12-2229-42 Anti-Human CD319 (CRACC) PE (162) 100 tests

产品名称：Anti-Human CD319 (CRACC) PE (162) 100 tests
产品货号：eBioscience 12-2229-42
产品规格：100 tests
Anti-Human CD319 (CRACC) PE
Also known as: CD2 like Receptor activating cytotoxic cells, CS1, SLAMF7
Clone: 162
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-2229
Cat. No. Size
12-2229-41  25 tests 
12-2229-42  100 tests 
Description: The monoclonal antibody 162 recognizes CRACC (CD2 like receptor for activating cytotoxic cells) also known as CD319 and CS1. It is a member of the SLAM receptor family. CRACC is a 66kDa glycosylated transmembrane protein which contains a cytoplasmic ITSM domain (Immunoreceptor Tyrosine-based Switch Motif). It is this domain, found in other proteins such as CD244 and NTB-A, that interacts with SH2 containing proteins such as SAP. Interestingly the ITSM domain in CRACC is SAP independent. Instead EAT-2 acts as the signaling molecule for CRACC. This has profound impact for patients with X-linked lymphoproliferative disease (contains a SAP mutation). It should be noted that a splice variant has been reported which deletes the ITSM domain.

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