eBioscience 12-1639-42 anti-human CD163 (M130) PE eBioGHI/61 (GHI/61) 100 tests

产品名称：anti-human CD163 (M130) PE eBioGHI/61 (GHI/61) 100 tests
产品货号：eBioscience 12-1639-42
产品规格：100 tests
Anti-Human CD163 PE
Also known as: M 130
Clone: eBioGHI/61 (GHI/61)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-1639
Cat. No. Size
12-1639-41  25 tests  
12-1639-42  100 tests 
Description: The eBioGHI/61 monoclonal antibody reacts with human CD163 (Haemoglobin Scavenger Receptor, M130), a member of the macrophage scavenger receptor family. CD163 is expressed by tissue macrophages, circulating blood monocytes, and some reports suggest that it may also be expressed by haematopoietic progenitor cells. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin which forms to clear haemoglobin from the blood. The high affinity for CD163 is specific for the haemoglobin-haptoglobin complex, whereas haemoglobin or haptoglobin display no to low affinity toward CD163. Upon ligand binding, CD163 initiates signal transduction which leads to the production of IL-6 and IL-10. Furthermore, it has been demonstrated that cytokines such as IL-6 and IL-10 can induce expression of CD163, whereas proinflammatory stimuli, such as LPS or TNFα, can cause shedding of a soluble form of CD163, whose function is unclear.

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