eBioscience 12-1520-80 anti-rat CD152 PE WKH203 25 ug

产品名称：anti-rat CD152 PE WKH203 25 ug
产品货号：eBioscience 12-1520-80
产品规格：25 ug
Anti-Rat CD152 (CTLA-4) PE
Also known as: CTLA4, Ly-56
Clone: WKH203
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-1520
Cat. No. Size
12-1520-80  25 ug 
12-1520-82  100 ug 
Description: The WKH203 monoclonal antibody reacts with rat CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.
 

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