eBioscience 12-0869-41 Anti-Human CD86 PE (IT2.2) 25 tests

产品名称：Anti-Human CD86 PE (IT2.2) 25 tests
产品货号：eBioscience 12-0869-41
产品规格：25 tests
Anti-Human CD86 (B7-2) PE
Also known as: B72, B70
Clone: IT2.2
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-0869
Cat. No. Size
12-0869-42  100 tests 
12-0869-41  25 tests 
12-0869-73  100 tests 
Description: The IT2.2 monoclonal antibody reacts with human CD86, an ~80 kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.
 

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