eBioscience 12-0748-41 Anti-Human CD74 (clone 5-329) PE, 25 tests

产品名称：Anti-Human CD74 (clone 5-329) PE, 25 tests
产品货号：eBioscience 12-0748-41
产品规格：25 tests
Anti-Human CD74 PE
Also known as: Invariant chain, MHC Class II-associated, Ia-gamma, Receptor for Macrophage Migration InhibitoryFactor
Clone: 5-329
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-0748
Cat. No. Size
12-0748-41  25 tests 
12-0748-42  100 tests 
Description: This 5-329 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43 kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NF\kappaB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.
 

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