eBioscience 12-0493-83 anti-mouse/rat CD49e (Integrin a5 chain, VLA-5A) PE eBio

产品名称：anti-mouse/rat CD49e (Integrin a5 chain, VLA-5A) PE eBioHMa5-1 (HMa5-1) 200 ug
产品货号：eBioscience 12-0493-83
产品规格：200 ug
Anti-Mouse/Rat CD49e (Integrin alpha 5) PE
Also known as: Integrin a5, ITGA5, VLA5A
Clone: eBioHMa5-1 (HMa5-1)
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 12-0493
Cat. No. Size
12-0493-81  50 ug 
12-0493-83  200 ug 
Description: The eBioHMα5-1 monoclonal antibody reacts with mouse and rat CD49e, also known as integrin α5 or VLA-5A. CD49e is a member of the integrin α chain family, and binds with CD29 (integrin β1) to form the receptor VLA-5, which binds the ligands fibronectin and fibrinogen. CD49e is a type I, single-pass membrane protein, with a molecular weight of 135 kDa, and is expressed on multiple cell types including thymocytes, mast cells, activated T cells and splenic B cells. In addition to its role in adhesion, VLA-5 contributes to T-cell co-stimulation. The eBioHMα5-1 monoclonal antibody has been demonstrated to interfere with VLA-5-mediated cell adhesion, and with the degranulation of IgE-sensitized rat RBL cells stimulated on fibronectin-coated plates. Furthermore, HMα5-1 injected into mice subcutaneously, along with anti-CD49d and anti-CD61, is able to inhibit passive cutaneous anaphylaxis.
 

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