Anti-Grim-19 FITC (1A8) 25 ug **

产品名称：Anti-Grim-19 FITC (1A8) 25 ug
产品货号：eBioscience 11-9937-80
产品规格：50 ug
Anti-Grim-19 FITC
Clone: 1A8
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 11-9937
11-9937-80  25 ug   
11-9937-82  100 ug 
Description: This 1A8 monoclonal antibody reacts with human, mouse, and rat Grim-19. This 16 kDa protein is expressed in many human tissues, especially in the heart and skeletal muscle. Lower expression levels of Grim-19 can be observed in the liver, kidney, and brain. Originally described as a nuclear protein, reports indicate that Grim-19 is primarily localized to mitochondria as an essential component of complex I of the electron transport chain. Grim-19 expression can be induced by interferon-β and all-trans-retinoic acid in tumor cell lines, leading to cell death. Finally, Grim-19 has been shown to bind the transactivation domain of STAT3 and inhibit its transcriptional activity. The molecular mechanisms of how Grim-19 regulates STAT3 within the cell remains under active investigation. 
 

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