Anti-Human/Non-Human Primate CD35 (clone E11) FITC,

产品名称：Anti-Human/Non-Human Primate CD35 (clone E11) FITC, 25 tests
产品货号：eBioscience 11-0359-41
产品规格：25 tests
Anti-Human/Non-Human Primate CD35 FITC
Also known as: Complement receptor 1, CR1, C3b/C4b receptor
Clone: E11
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 11-0359
Cat. No. Size
11-0359-41  25 tests 
11-0359-42  100 tests 
Description: This E11 monoclonal antibody reacts with human and non-human primate CD35, which is also known as complement receptor 1 (CR1). CD35 is expressed on B cells, T cell subsets, follicular dendritic cells, macrophages, neutrophils, eosinophils, and erythrocytes. This cell surface protein is also present on non-immune cells such as glomerular podocytes and Langerhans cells. CD35 binds the complement components C3b and C4b, which are derived from cleavage of C3 and C4, respectively, in the classical and alternative complement pathways. In humans, CD35 has been implicated in a variety of roles, including complement activation, transporting C3 complexes on erythrocytes, phagocytosis of complement-bound neutrophils and macrophages, B cell proliferation, and opsonization. Reports also indicate that Plasmodium falciparum, the pathogen that causes malaria, invades host erythrocytes by binding CD35. Decreased expression of CD35 on erythrocytes has been associated with systemic lupus erythematosus (SLE), type I diabetes, and rheumatoid arthritis.
The E11 antibody has been reported to crossreact to capuchin monkey, chimpanzee, cynomologus monkey, olive baboon, and rhesus macaque. 
 

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