Paclitaxel 紫杉醇

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assay ≥95% (HPLC) Paclitaxel
分子量: 853.91
CAS号: 33069-62-4
经验分子式(希尔表示法): C47H51NO14
Caution
Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
包装
1, 5, 25 mg in glass btl
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).
相关类型 Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
Antitumor Agents, Antiviral, Apoptosis Product Bundle, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cancer Research, Cell Biology, Chemical Structure Class, Drug and Xenobiotic Metabolism, Interferes with DNA Synthesis, Mechanism of Action, Microtubule Inhibitors, Multi-Drug Resistance and Drug Metabolism, P, Spectrum of Activity, Substrates, Inducers, Inhibitors, Taxoides
biological source from Taxus brevifolia
form powder
color white
mp 213 °C (dec.)(lit.)
solubility DMSO: soluble50 mg/mL (can be stored frozen for several months)
  H2O: soluble (hydrolyzes)
  ethanol: soluble
  methanol: soluble (undergoes transesterification)
storage temp. 2-8°C
 

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