Anti-Human CD58 (LFA-3) APC (TS2/9) **

产品名称：Anti-Human CD58 (LFA-3) APC (TS2/9) 100 tests
产品货号：eBioscience 17-0578-42
产品规格：100 tests
Anti-Human CD58 (LFA-3) APC
Also known as: LFA3
Clone: TS2/9
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 17-0578
Cat. No. Size
17-0578-41  25 tests 
17-0578-42  100 tests 
Description: The TS2/9 antibody recognizes human CD58, which is also known as Lymphocyte Associated Antigen-3 (LFA-3). CD58 exists both as a transmembrane protein as well as a GPI-linked extracellular protein. It has been shown that cells can express both forms concurrently. In addition, soluble CD58 has also been observed in serum, urine and synoval fluid of rheumatoid arthritis patients. CD58 is found on non-hematopoietic and most hematopoietic cells. Binding to its ligand CD2, which is present on T cells, initiates a signaling pathway which includes phosphorylation and results in release of cytokines. CD58 has been shown to be important in adhesion to various cell types, T cell activation, cytokine production and cytoxicity.
The TS2/9 antibody has been reported to induce signaling events upon crosslinking. The epitope is in domain 1 of the immunoglobulin region.

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