亮抑酶肽, Leupeptin hemisulfate salt,亮肽素,Acetyl-Leu-Leu-Arg-al,Acetyl-Leu-Leu-Arg-a

Synonym:

Acetyl-Leu-Leu-Arg-al, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt

CAS Number:

103476-89-7

Linear Formula:

C₂₀H₃₈N₆O₄ · 1/2H₂SO₄

Molecular Weight:

475.59

MDL number:

MFCD00037012

PubChem Substance ID:

24896328

Analysis Note

Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin.

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain and cathepsin B. No inhibition found with pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.

biological source

microbial

assay

≥90% (HPLC)

EQP level

Premium

solubility

H₂O: 10 mM (Solutions are stable for a week at 4 °C. Stock solutions are stable up to 6 months at −20 °C.)

storage temp.

−20°C

Personal Protective Equipment

Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Safety Statements

22-24/25

WGK Germany

3

reference

Aoyagi, T., Inhibitor of trypsin, plasmin, papain and cathepsin B. J. Antibiot. 22, 283, (1969)

Saino, T., et al. Chem. Pharm. Bull. 30, 2319, (1982)

Deutscher, M.P., Maintaining protein stability. Meth. Enzymol. 182, 83-89, (1990)

Jazwinski, S.M., Preparation of extracts from yeast. Meth. Enzymol. 182, 154-174, (1990)

, Beynon, R.J. and Bond, ed. Proteolytic Enzymes: A Practical Approach, (1989), 244-245

品名

产地

货号

规格

单价

备注

亮抑酶肽Leupeptin

SIGMA

L2884

5MG

询价

现货