β-Estradiol,β-雌二醇,17β-diol, 17β-Estradiol, Dihydrofolliculin

β-Estradiol β-雌二醇

Sigma  E2257  β-Estradiol

powder, BioXtra, γ-irradiated, suitable for cell culture

Synonym: 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

CAS Number: 50-28-2

Empirical Formula (Hill Notation): C18H24O2

Molecular Weight: 272.38

Beilstein Registry Number: 1914275

EC Number: 200-023-8

MDL number: MFCD00003693

PubChem Substance ID: 24894462

Description:

Application β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).

Reconstitution To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

Physical form powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Biochem/physiol Actions The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

APPEARANCE: WHITE TO OFF-WHITE POWDER

SOLUBILITY :CLEAR COLORLESS SOLUTION AT 1 MG/ML OF ETHANOL

PURITY BY HPLC: > OR = 98%

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