Amethopterin,4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid,氨基碟

Synonym:

4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid

CAS Number:

54-62-6

Linear Formula:

C₁₉H₂₀N₈O₅

Molecular Weight:

440.41

Beilstein Registry Number:

69045

EC Number:

200-209-9

MDL number:

MFCD00036692

PubChem Substance ID:

24278186

Linkage

More potent, but more toxic, than methotrexate.

Biochem/physiol Actions

Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.

assay

~98% (TLC)

form

powder

color

yellow

solubility

2 M NaOH: 50 mg/mL (Solutions may be stored for 1-2 days at 4°C.)

DMSO: soluble (Solutions may be stored for 1-2 days at 4°C.)

abs.

ε1M/261 nm, 0.1 M NaOH 25,700

ε1M/282 nm, 0.1 M NaOH 24,500

ε1M/373 nm, 0.1 M NaOH 8,100

Gene Information

human ... FPGS(2356)

mouse ... Fpgs(14287)

storage temp.

−20°C

Personal Protective Equipment

Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes

T+

Risk Statements

61-28

Safety Statements

53-28-36/37-45

RIDADR

UN2811 6.1/PG 1

WGK Germany

3

RTECS

MA1050000

品名

产地

货号

规格

单价

备注

Amethopterin/氨基碟呤/氨碟呤

Sigma

A1784

5mg

询价

现货

Amethopterin/氨基碟呤/氨碟呤

Sigma

A1784

25mg

询价

现货