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merck 420119-5MG SP600125,SP 600125,SP-600125,JNK Inhibitor II 现货

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产品名称: merck 420119-5MG SP600125,SP 600125,SP-600125,JNK Inhibitor II 现货
产品型号: merck 420119-5MG
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merck 420119-5MG SP600125,SP 600125,SP-600125,JNK Inhibitor II 现货


merck 420119-5MG SP600125,SP 600125,SP-600125,JNK Inhibitor II 现货  的详细介绍
merck 420119-5MG SP600125,SP 600125,SP-600125,JNK Inhibitor II 现货

SP600125

 

MERCK相关产品资料：

420119  JNK Inhibitor II ( JNK Inhibitor II )
Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II

A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.

Product number

型号

价格

420119-5MG

5 mg

询价

 

产品信息

Form

Yellowish orange solid

Primary Target

JNK 1, JNK 2, JNK 3

Primary Target IC50

40 nM, 40 nM, 90 nM

Molar mass

220.2

Protect from Light

Yes

Packaged under inert gas

Yes

Cell permeable

Yes

Reversible

Yes

ATP Competitive

Yes

Purity

≥98% by HPLC

Solubility

DMSO

Chemical formula

C14H8N2O

RTECS

CB4585000

CAS number

129-56-6

 

Store and ship information

 

Storage

-20°C

Ship

Ambient Temperature Only
Standard Handling

 

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