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LY 294002,LY294002,LY-294002

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产品名称: LY 294002,LY294002,LY-294002
产品型号: Merck 440202-5MG
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简单介绍

LY 294002,LY294002,LY-294002


LY 294002,LY294002,LY-294002  的详细介绍
LY 294002,LY294002,LY-294002

LY 294002

MERCK相关产品资料：

440202  LY 294002 ( LY 294002 )

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available.

Product number

型号

价格

440202-5MG

5 mg 

询价

 

 

产品信息

Form

Off-white solid

Primary Target

specific phosphatidylinositol 3-kinase inhibitor

Primary Target IC50

1.4 µM

Molar mass

307.4

Protect from Light

Yes

Cell permeable

Yes

Purity

≥98% by HPLC

Solubility

DMSO or EtOH

Chemical formula

C19H17NO3

CAS number

154447-36-6

 

Store and ship information

 

Storage

-20°C

Ship

Ambient Temperature Only
Standard Handling

 

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