soluble α-Klotho human ELISA

产品名称：soluble α-Klotho human ELISA
产    地：Demeditec 
产品货号：JP27998
产品规格：96 Tests
产品说明：
Special remarks:
INTRODUCTION
“α-klotho”    was    identified    as    an    extremely    down-regulated    gene    in    the genetically-modified mouse of which phenotype is very similar to various symptoms of  human  aging.  Then,  the  sequences  of  α-klotho  genes  have  been  identified  in various species including humans based on the one of mouse. α-Klotho protein is a 130 kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands. 
In recent years, it has become clear that α-Klotho is an important molecule within a living  organism  regulating  the  metabolism  of  mineral  such  as  calcium  and phosphorus.  Therefore,  it  is  considered  that,  in  α-klotho  mouse,  early  aging-like symptoms  are  induced  by  impaired  mineral  homeostasis  caused  by  decreased expression   of   α-Klotho.   Meanwhile,   it   is   reported   that   the   long   N-terminal extracellular  domain  which  comprises  the  major  portion  of  sequence  of  α-Klotho protein is released free into blood by shedding. However, there are  many  unclear points  about  functions  and  changes  in  concentration  of  free  (soluble)  α-Klotho protein, so it has been required to develop the measurement system of α-Klotho.
This ELISA kit can measure Human soluble α-Klotho protein in human blood.
PRINCIPLE
This kit is a solid phase sandwich ELISA using 2 kinds of highly specific antibodies.
Tetra  Methyl  Benzidine  (TMB)  is  used  as  a  coloring  agent  (Chromogen).  The strength of coloring is proportional to the quantities of Human soluble α-Klotho.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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