Tenascin-C Large (FNIII-B) ELISA

产品名称：Tenascin-C Large (FNIII-B) ELISA
产    地：Demeditec 
产品货号：JP27767
产品规格：96 Tests
产品说明：
Special remarks: This test kit can be used for serum and EDTA plasma samples originating from humans, rat, and mouse. It also can be used for cell culture supernatant. There is also another testkit available for the measurement of the Tenascin-C large variant including domain FNIII-C (cat.-no. JP27751).
Tenascin-C is an extracellular matrix (ECM) glycoprotein that is composed of 210-400 kDa subunits consisting of four domains. One subunit has a TA domain at the N-terminal end, then an epidermal growth factor-like sequence domain (EGF-like domain), a fibronectin type III(FNIII) repeat domain, and a fibrinogen-like domain at the C-terminal end. There is an alternatively spliced domain in the FNIII domain, and it generates some types of variants of Tenascin-C. The subunits form a trimer by twisting at the N-terminal coiled domain and form a hexamer by a disulfide bond, in tissue. While low molecular weight variants of Tenascin-C are present in normal tissue, it is said that high molecular variants of Tenascen-C is expressed in various diseased tissue including cancer.
This kit can detect the Tenascin-C high molecular weight variant including the subunit in which FNⅢ-B domain specifically, by using two different kinds of specific antibodies.
“Large” in the product name means “high molecular weight variant”
Coating Antibody: Anti-Tenascin-C (4C8MS) Mouse IgG MoAb; affinity purified; specific to FNIII-B domain.
Labeled Antibody: HRP conjugated Anti-Tenascin-C (4F10TT) Mouse IgG; Fab’ affinity purified; reacts with the EGF-like domain.
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