Angiopoietin-like 4 human ELISA

产品名称：Angiopoietin-like 4 human ELISA
产    地：Demeditec 
产品货号：JP27749
产品规格：96 Tests
产品说明：
Special remarks:
INTRODUCTION
Angiopoetin-like  4  (ANGPTL4)  is  a  member  of  the  angiopoietin/ANGPTL  family. Human ANGPTL4 consists of 406 amino acids. Its protein structure is common to the angiopoietins, with a signal peptide directing secretion, an N-terminal coiled-coil domain (CCD), a linker, and a C-terminal fibrinogen-like domain (FLD). Full-length ANGPTL4  is  secreted  by  liver  and  adipose  tissues  and  cleaved  to  generate circulating  CCD  and  FLD  fragments.  ANGPTL4  plays  important  roles  in  lipid  and glucose  metabolism.  It  inhibits  lipoprotein  lipase  (LPL)  activity  by  breaking  the dimmer molecule, and elevates plasma TG level. Meanwhile, it is also implicated in breast cancer metastasis to lung via the regulation of vascular integrity.
Both  of  two  antibodies  used  in  this  ELISA  kit  recognize  the  N-terminal  portion  of human ANGPTL4 respectively.
PRINCIPLE
This kit is a solid phase sandwich ELISA using 2 kinds of highly specific antibodies. Tetra  Methyl  Benzidine  (TMB)  is  used  as  a  coloring  agent  (Chromogen).  The strength of coloring is proportional to the quantities of Human ANGPTL4.
INTENDED USE
This kit is capable for the quantitative determination human ANGPTL4 in serum and EDTA-plasma. In  the  case  of  normal  individuals,  many  of  blood  samples  will  fall  below  the sensitivity. When cell culture media is measured, some suitable arrangements are required (for  example,  negative  media  control)  since  some  FBS  (FCS)  will  be  measured high level ANGPTL4 with this kit.
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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