25(OH) Vitamin D3 RIA

产品名称：25(OH) Vitamin D3 RIA
产    地：Demeditec 
产品货号：DEKIP1961
产品规格：96 Tests
产品说明：
Special remarks:
Physiological function of 25OH-Vit.D3.
25-Hydroxyvitamin D3 (25OHD3) is the trivial name of 9, 10-secocholesta-5, 7, 10(19)-triene-3b, 25-diol. This secostroid is produced in the liver by 25-hydroxylation of cholecalciferol or Vitamin D3. 25OHD3 is a precursor for other Viamin D metabolites and has only a limited biologiccal activity in itself. The most active derivative is 1a,25-Hydroxyvitamin D3, produced in the kidney (or placenta) by 1a-hydroxylation of 25OHD3. This hormonally regulated steroid stimulates the intestinal absorption of both calcium and phosphorus. It also stimulates bone resorption and mineralization thereby preventing the development of rickets or osteomalacia. This Vitamin D hormone might also be active in other tissues responsible for calcium transport (placenta, kidney, mammary gland,..) and endocrine glands (beta-cells, parathyroid glands, ...), 25-hydroxyvitamin D3 is a main precursor for the metabolites.
Regulatory mechanism
The production of 25-hydroxyvitamin D mainly occurs in the liver although other tissues (intestine, kidney) might perform the same hydroxylation. Although there might be some feed-back inhibition of 25-hydroxyvitamin D on its own production, a higher substrate availability (Vitamin D3) results in higher 25-hydroxyvitamin D production and higher circulating 25-hydroxyvitamin D concentrations in blood. No hormonal or other regulatory mechanism for its synthesis have been clearly identified.
Clinical application for 25OH-Vit.D3 Assay
This assay is of importance for the diagnosis of Vitamin D deficiency or intoxication
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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