Resistin ELISA

产品名称：Resistin ELISA
产    地：Demeditec 
产品货号：DEE050
产品规格：96 Tests
产品说明：
Special remarks:
INTRODUCTION
Resistin, a cysteine-rich protein of 11.3 kDa, was firstly found in mice and constitutes together with RELMa, RELMb and RELMg the protein family of resistin-like molecules (RELM).
In humans, resistin and RELMb  but no other proteins of the RELM family were found. The human form of resistin shows a homology of 53% to the murine protein. It has 11 cysteine-residues, is synthesized as a propetide of 108 amino acids and secreted as a dimer, build by a disulfide bridge of cysteine residues. Beside this intermolecular disulfide bridge, 5 additional intramolecular ones exist.
Appearance of multi- and oligomer formation was proved by size exclusion chromatography. Thereby it was shown, that oligomer formation is SDS-insensitive but can be inhibited by β-mercaptoethanol and is therefore likely to be caused by disulfide bridges.  Further on, the resistin structure seems to be dependent on its concentration, as circular dichroism analysis shows a concentration dependent shift of a-helical to b-sheet structure.
Resistin expression was demonstrated in white adipose tissue, pituitary and pancreatic islets of mice as well as in brown adipose tissue of rats. In humans, resistin expression in adipocytes can be detected but only at a very low level. But in vitro, resistin expression of non-adipocytes in fatty tissue was shown. Human resistin gene is also expressed in pancreatic islets , pre-adipocytes marcophages  and bone marrow. So, resistin is of relevance for inflammation processes as well as for lipid metabolism.
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