Adiponectin human

产品名称：Adiponectin human
产    地：Demeditec 
产品货号：DEE009
产品规格：96 Tests
产品说明：
Special remarks: Adiponectin is a 30kDa protein which percentage in serum proteins is 0.01%. It is mainly synthesized by Adipocytes, but also muscle cells and hepatocytes have the ability to synthesize Adiponectin. Until now, IGF-I is the only known natural inductor of the synthesis. It consists of  a Collagen-like N-terminal and a globular C-terminal domain. In vivo Adiponectin appears with different oligomers. Beside the trimer and ditrimer also high molecular multimers exist. Up to now two different receptors are known, both receptors are ubiquitary expressed, though the distribution in the tissues varies. The Adiponectin Receptor 1 (AdipoR1) is especially in muscle- and AdipoR2 in liver tissue synthesized.
The significance for the human organism is not clear until now. First studies show, that adiponectin correlates negatively with BMI and thus it could have relevance for the energy metabolism for example through the regulation of fatty acid oxidation. Beside the correlation with BMI, Adiponectin level is associated with the Insulin-Resistance and so also linked with Type II Diabetes. Adiponectin is associated also with glucose- und lipometabolism.
The formerly proposed diagnostic value of the high molecular weight form of adiponectin was not verified using a commercially available testsystem for the determination of HMW adiponectin. Blueher et al. clearly demonstrate that regarding the diagnosis of insulin resistance, measured by whole body glucose uptake below 40 µmol/kg*min, total adiponectin as determined with this testkit, is with an area of 0.92 under the receiver-operating curve, of greater diagnostic value.
Furthermore it is involved in inflammatory processes and therewith it is of importance for appearance of arteriosclerosis and coronaritis, thus the determination of Adiponectin level  in plasma could serve to estimate the risk of coronary disease. Beside this Adiponectin influences further physiological processes as for example the angiogenesis.
Test principle: This ELISA testkit for the measurement of Adiponectin is a so-called  Sandwich-Assay using two specific and high affinity antibodies. The Adiponectin in the samples binds to the first antibody coated on the microtiter plate. In the following step the second specific anti-Adiponectin-Antibody binds in turn to the immobilised Adiponectin. The second antibody  is biotinylated and will be applied in a mixture with a Streptavidin-Peroxidase-Enzyme conjugate. In the following substrate reaction the turn of the colour will be catalysed quantitatively depending on the Adiponectin-level of the samples.
The standards of this testkit are prepared from native Adiponectin (human origine).
上海玉博生物技术有限公司在为生命科学领域提供丰富的产品与信息资源方面处于国内**地位，公司提供的产品涵盖了二十多个国家近五十万种产品，而且产品的数量与信息在不断的增长和更新，公司提供的产品能够使生命科学工作者加快对生物化学，分子生物学，细胞生物学以及蛋白质组学研究的认知，以及分子诊断和临床医学领域的应用。

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